I got this to work once with an all English side to win the Premiership on FM11. Not tried the same tactic on FM12 yet, but a few things to bear in mind to make it work:
By nature, a poacher hardly contributes to possession, having two on the field will mean virtually any chance of holding onto possession will be out the window, it's virtually like you're playing with 8 outfiled players from the start. My conclusion was as a result to go with this idea, can't hold possession, no point in trying, play a counter attacking game.
Then think about how your poachers are going to get the service if they don't get too much possession, you still want them to get a lot of chances (let's face it, a good poacher will usually score if he gets 2 clear cut chances a game). And we know that the best chance of a poacher getting a CCC is a through ball. For this to work, no matter how many midfielders you use, they will all need some quality in passing, creativity + ideally the tries through balls often PPM.
Seeing as how you'll be using two poachers, it would help confuse defenders for marking if you get them exchanging positions with each other on player instructions.
Last thing you want to consider if you take my approach, most of the time the best poachers have pace, that seems to be the case for quintero and doumbia, a rapid pace of play should help catch opposition defenders off guard and play to your poacher's strengths.
Can't remember all my team but my line up was a flat 442, Delfouneso and Campbell up front (they both finished on over 20 league goals each), downing on the left wing (through balls often highlighted), Delph as my advanced playmaker, Rodwell as a ball winner, right wing some pacey regen with good passing.
All the midfield got good assists except for Rodwell, then again that wasn't his job
