23 plus 11 youths - two seniors and one talent for each position, with an extra keeper.
However, I find that when I get a squad like that I often loose interest in the game - so even though I find the above to be the most efficient setup I usually try to rotate players a bit more between...
I think you should look for a tactic that fits the team, rather than the leauge. That said it can be a good idea to consider what tactics you are likely to be up against as some formations do well against others etc.
In FM10 my experience with 442 has been limited to a game with Rotherham, byt...