I am currently Spurs boss and have just entered my 3rd season, my team looks like this:
GK Akinfeev
DR Corluka
DL Bale
DC Coloccini
DC King
MR Bentley
ML Srna
FC Podolski
FC Falcao
This seems to work really well for me and not many injuries suffered but have a few players in reserve to back...