1. You will never dominate the middle with just two men, so turn off retain possession(which also conflicts with "pass into space") and exploit middle. You may counter this with making one winger an inside forward. Otherwise your midfielders will have trouble getting the ball into attack.
2. Hassling opponents might prove futile as a three man midfield/defense can play their way out of pressure and find a huge amount of space between the lines.
3. You may want to make the DLP have a defend duty so there's someone who reduces the gap between the lines.
4. You may want to drop the wingers back into a flat midfield 4 as wide midfielders, but with team instructions to give them more creativity(more risky passes) and to sit narrow. This is due to the distance between the winger and the opposition fullback, so he has a lot of time to pick out a pass for the poacher. The sit narrow instruction means he can help out in the midfield battles and make a formidable wall hard to break through.