I'd suggest a couple of issues going on here...
First one is the form of your players varying so wildly (assuming that this is a regular thing for them to have a good match followed by a bad match). Either they are inconsistent performers or you are not motivating them properly with your teamtalks. Are you overpraising them so in the next match they are too complacent? My gut feeling is that their fluctuating form is down to your teamtalks. Review whether you are having any impact upon players with the teamtalks by getting the assistant manager's feedback for each one you give. Also check the 'motivation' screen (Home Stats or Away Stats in match, choose the 'view' option and then choose 'motivation'). This will tell you if a player is feeling nervous or complacent during the game. Always worth checking before giving your half-time teamtalk. So a nervous player may need to be told he's under no pressure. A player with low morale may need to be told you have faith in his ability. A player who is showing complacency may need to be told you're not impressed with his performance. It seems like different personalities respond to different teamtalks in different ways, so worth keeping an eye out for things that work and things that don't for specific players.
As for your tactics... well, there is a slight advantage always given to the home team. They perform 6% better than they would do if they were playing away from home. Thing to watch out for with the big teams is that if you attack too much and don't concede then the little teams will frequently nick a goal with a counterattack. So play a little more cautiously, not too much, but try to control the game and build up pressure by lowering things like the tempo a little and increasing things like creative freedom just a bit more for your attacking players. The best way to figure out what's going wrong is to watch a few matches in full and to spot what's happening which is making your tactics less effective away from home. Could be that teams aren't being quite so defensive and so finding weak spots in your tactics or it could be that your tactics aren't patient enough to get through a well organised defence which has the home crowd behind it.
Radically changing tactics won't work when reloading games btw. It takes a few games before the team will 'adapt' to a new mentality structure or totally different style of play. Replaying matches using different tactics will rarely help much for that reason, far better to tweak the tactic/s which you use regularly so that they work for that particular game. Of course, you could eventually stumble upon that tactic which hides all your team's frailties while finding out key ones in the opposition but that would be a very long and boring way to play the game for me
I'll try that stuff out and let you know how it goes 
My clearances will go straight to the opposition 99% of the time and theirs will go to their players resulting in counter-attacks. Although to be honest they arn't the problem, it's usually the mass amount of corners I concede after poor clearances; eventually resulting in goals, and then my players just not being able to equalise.
