Trequartista's work really well with another striker alongside, such as a target man or poacher. I've never tried a trequartista up front on their own, but I'd imagine it would work quite well as long as you had Wingers cutting in from AML and AMR. What formation are you currently playing? Possibly try him as an Advanced Forward or as a Deep Lying Forward, if you have Wingers and Attacking Midfielders who will run ahead of him if necesary.