Have you got good concentration and determination stats for defensive players?
What age are your defensive players? Might need someone experienced.
Is your goal keeper commanding? Does he have any weaknesses being exploited?
Players might not have a winning mentality and will need telling before a game not to get complacent. That said, be very careful. If you're on a bad run, having a go at your players will only make matters worse, in which case use motivational and encouraging phrases. I say this because top players will mostly respond well, poor players get angry, become distressed or lose interest.
My Spurs save is a good example. I like to use plug and play as much as possible.
1st season defensive players were Friedel, Gomez, Walker, Vrisjalko, Dawson, Kaboul, King, Gallas, Essou Ekkotto and M'bengue. Overall the age was very young and back line made odd silly mistake. I definitely found concentraion a problem and late goals were coneeded.
2nd season, players a year older, more games played together. Bought Handanovic (Gk) and Mangane (CB). Results were amazing once players were used to tactics on prep screen. A brilliant keeper makes a huge difference. Friedel and Gomez are good, but Handanovic was saving things thay couldn't. Mangane added experience for a year, pulled up the avergae age of the back line and I believe this made a huge difference in not conceeding after scoring early on.
5th season in and though I only lose 2-3 games in all competitions, goals conceeded are slighlty higher. I believe this is because of the blooding of youngsters. Difference is that where as before I would draw/lose a game after going one up, I now concede late, but have already scored 4 or more goals!
I use the example above, because though people say tweak this, tweak that, it's really down to players and team talks. I'm using the same tactic 5 seasons in, but the results improve year on year as I get better players.