My best suggestion would be for you to decide what you want from the save.If you just want to plug & play and develop youngsters, then I would pick a team like Barca or Real but if really wanting to get into the save and wanting it to bring more dimensions, the I would do the following
- Make some research about the squad. Look at it as it where in real life. If picking Aston Villa, then you should expect to struggle in some matches, correct ? The next thing is to analyze their squad and the players. Looking at a random player in their team, you will see his strengths and weakneses. This way, you will easier understand why he gives away the ball in dangerous positions, or why he struggles in big matches.
My point is that when knowing all this, then you decide if you like this approach or not. If so, then make some goals with the save. It could be to actually develop some players and finding that just as important as getting 3 points in that particular match.
Never reload a game. Take a loss on the chin and instead try to learn how to get the morale up after a few losses, try becoming a better coach and mentor.