GK: De Gea is a beast, get Sam Johnstone some game time, he's good - English too. ter Stegen or Koval if you want a new one.
LB: Shaw or Davies to understudy Evra. Alaba for instant impact, although he will cost. Jonathan Silva is good in some saves as well.
CB: Marquinhos, Umtiti, Zouma (Unless you're in 14.3), Balanta or Doria. I also managed to get Varane for ?25m in the second season.
RB: Rafael has years in him. Corchia, De Sciglio or Peruzzi as back ups.
CDM: Kondogbia - He's TOO good. Diego Reyes in the second season. Get Vidal if you have money in the future.
CM: One word... Pogba. Kroos if you have money in the future. Powell turns out to be a good player also, so get him some game time when he returns from loan. Ward-Prowse is a bright english CM with loads of potential. Varratti is a don as well - cheap sometimes too.
AML: If you decide to eventually play Januzaj in the middle? Thauvin, Bernard, El Sharaawy (Injury prone) and Vitinho can be good. Draxler if you have the money (?39m release clause). Reus if you can steer him away from Bayern and pay the release clause (?29m).
AMR: Wellinton Nem as always. Chamberlain if you can get him. Lucas Moura and Deulofeu are decent too.
AMC: Play Mata, Januzaj (if he's not on the left) or Kagawa here! If you want a new one: Quintero is a king. Meyer, Otavio or Paredes have bags of potential. Barkley is a great English option.
ST: Play Rooney after RVP dips/leaves/retires. Mitrovic is crazy good in the future. Volland is also superb, but you need to get him in the first season as he becomes expensive. Benzia and Berardi are great youth options. Adam Campbell has good potential for an Englishman. Jese is a bright spark too.
Other than the above... Regens all the way!