What I've done in my Wolves save is I have my first team play the tough games and Euro games. Then for all the other games I use my "Future" team. This is a team that was all bought by me while they were 18 or younger or came through my system that is good enough for softer competition in Prem, they are all 18 or older to be called up to 1st team, I have a hard time playing anyone younger. So far in my latest season, I have played my 1st team about 25 games by April. My Future team has about 14 starts. It's really nice having that solid team of youngsters to rest my 1st team. And they are all gelling together well. In a few years they will be my 1st team and I'll have another future team coming through.
Development wise, it's working well. I've only been told that one of my youngin's needs more 1st team action to develop better, but this kid is just world class. I also have a surplus of center mids. I send out the worst ones out, and they will most likely be Seller Fodder. I still have a really good AMC and Striker in my U18s. And just had a new wave of kids come through and I have a very promising Fullback. He may become a "Good" Prem right-back, 3-star.