Pretty much what Sparty said, but just a few additions.
If you have a quick CM, set him as a box to box (or at least set his run from deep to often), and let the DLP deal with distro. Playing with quick players is all about playing on the break, so you want as many players rushing forward at once as possible. Similarly, you'll want offensive fullbacks running from deep often (this also helps with the lack of width inverted wingers creates). The anchor man, CBs, and playmaker all need to stay very deep. You'll want the CBs and Anchor Man to have passing set to very short (unless they have 15+ in passing, creativity and decisions), and the DLP to long, with through balls often. The offensive set up depends on the players at your disposal, but as a rule of thumb, adv forward or poacher will be best as you don't want them dropping deep.
Another option to consider is to play with 3 strikers rather than 1 striker and 2 wingers, with the 2 wides strikers set to specifically mark the corrosponding fullback to stop you getting overrun in defense (you have to set specific marking in match, but you can save it after, then re-load it after the match and it will stay like that). But again, depends on players.