Used the 4231 in all league games and cup. 41221 used in all Champions League games. Felt I needed some more defensive stability so moved the AMC to DM. In my other saves I´ve just used the 4231. Just plug and play. One tweak I will maybe do in the future is changing the BBM in the 41221 formation to a MEZ-a in games I should be dominating. And then swapping the DLP and MEZ around.