I have I am trying this with Barcelona.
I started using "4-3-3 Narrow" from the standard formations.
Team instructions I have tried are:
Get stuck in (let's be brutal)
Hassle Opponents
Narrow the Play (Better possession)
Shorted Passing (Better possession)
Push Defence Up (Better possession)
I was getting around 40 shots per game. Defense seems a bit leaky against defensive/counter attacking teams although I easily beat Madrid & Man City. I am changing the odd 1 team instruction or 1 player role at time to see how it works.
I set the general team instructions to Attacking too which allows the full backs to run down the wings. They don't seem to good so maybe I will remove Narrow the Play option to get them move involved. However this usually means I have less possession.
I have switched one of the MCs to Roaming Playmaker. So in the middle I have Defensive MC, Automatic MC, Roamy Plmkr. This has actually caused the shots per game for my opponents to drop to around 1-2, whereas I still have 40+. But I'm still getting some 0-0 scores. Messi is playing OK, but nowhere near his potential. It's getting gradually better. My best goal scoring position seems the be the Deep Lying Forward (Support) which is weird.