Exactly the same thing's been happening to me as well (and I'm playing Spurs -- maybe it's the curse of North London). Extremely frustrating becasue I'll ply for 45 minutes and need to completely start over again. It didn't happen in the Beta version so I'm hoping there will either be some trick to fix it, or a bug update come from the folks at SI soon.
Same thing happened to me, you can still save the game you just have to press ctrl+q and the pop up loads in front of that screen. Exit the game and start it up and the loading screen has gone. Pain I know but less of a pain than losing three weeks!