I was using a 4-3-3 with Wing backs and a Regista at the start and was scoring a ton but I later changed to a 5-3-2 WB to improve the defending and used that from around november onwards.
5-3-2 Tactic - http://www.fm-base.co.uk/forum/share-download-fm-15-tactics/183787-duzzy-5-3-2-van-gaal.html