Depends a lot on what formation you use.
Using a 4231 I find playing Juve and their 352 pretty easy going because I can just attack down the wings on the counter. Pulls the CBs apart and my ST is often left alone.
4-4-2 diamond (DM, LW, RW, AM). Absolutely slaughtered Chelsea with Bristol City - 3-1 home and away - when they were using this formation. I was playing a classic 4-2-3-1 possession game and there was no-one trying to get the ball off us. At all.