It should be more safe against smaller opposition due to them being weaker and less able to exploit the reduced space.
IT all depends if you have players who can play in that way
I had lots of problems setting it up with my 4 2 3 1 but got a few intelligent CB , turned off use offside trap and switched the MC to DMC , switched one CB to Cover and in my 3rd year with Dinamo playing in the champions league playoffs eventho i had Juventus Chelsea and Valencia ( lost only 1 game 6 4 to chelsea 5 goals from set pieces)
But everything can work , u just have to figure out if you have the personal for it or how it fits with the rest of your tactics