Well, for one thing, Look for Overlap doesn't work with Work Ball Into Box. One of the main points of overlapping runs is to get fullbacks in space so that they can cross, and Work Ball Into Box discourages crossing, if I remember correctly. You also have Pass Into Space, which conflicts with Play Out Of Defense; Pass Into Space encourages more direct passes into voids left by the opposition, so one instruction is telling your defenders to play it long and quick into open space while the other is telling them to pass it short to the feet of their teammates. I also doubt you have enough protection for your back line, even with a CM in Defend duty.
I'm not exactly sure what you're trying to accomplish with this tactic. It would also help, as WJ said, to know what specific problems you're encountering.