Well, injuries depend on injury proneness, chances of a past injury recurring, pitch condition, physios, pressing and tempo of you play as well as squad rotation. However, I have managed three of the injured players and they rarely get injured playing a heavy pressing, fast tempo game but all the other factors are low risk. Injury proneness is often left to chance in every game due to the fact that very few players have a number in that field entered by the research team.
Another problem is possibly the fitness focus, never set fitness focus as it often causes injuries and lowers player condition, making them more likely to pick up injuries.