I used a similar tactic with Nápoles and i had great results (11.2)
It was 3-1-2-2-2
1 tall CB as Stopper (Strong, high positioning. heading is a plus. like Sakho*, Adil Rami, Kara, Fazio) in the center, 2 Cb's as Cover (High aceleration and high anticipation. like Otamendi*) in the left and right.
1 DMC as Anchor Man (Strong, high anticipation, high tackling, high positioning. Like Anthony Annan*,N'Zonzi, Kara)
2 MC one Box to box (complete player. long shoots is a plus like moussa sissoko*, vukcevic, veloso) and one Advanced playmaker (Creativity, passing, team work, technicke. Like nuri sahin, Darío Conca*, Arda Turan, Sigurosson)
2 Wingers or Inside forward depends on the players. players like kalou i preffer Attack role(quick players good dribblers, but not good passers) and Support (more creative player good passers). I used Elijero elia as inside forward attack in the left and Matías Schelotto as winger on the right with my napoli save. Then i bought Alexis Sanchez as back up.
2 Strikers. (Lavezzi and Cavani are great together). I used lavezzi as pocher/adv forward in the right Cavani in the left as Target man or complete forward ( Cavani in the left receive the crosses 2 right footed playing in the right lavezzi and schelotto ). Target man Cavani Mixed and Float Crosses. I bought Paloschi as Lavezzi back up.
Use a control mentality, and reduce the creativity of all the players except the MC`s. You will have high possesion.. and a lot of chances.
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Good Luck!