I have tried some of the strikerless variations, and all work sort of well. I do find, however, that dual striker formations tend to be more potent in FM15. Nevertheless, with quality players, you can win with just about any logical tactic.
If you are going with a 4-6-0 then I think it makes sense to use one of the AMC spots as a shadow striker. The other would be a playmaker type of role (T, E, or AP). The central midfielders should be more defensively minded, although their ability to play through balls will prove invaluable. When it works, the goals from strikerless tactics are beautiful.