It doesn't make a huge difference, but things like the run settings can affect things.
If you put a left footed striker as STCL and set him to run into channels then he will run in between the right back and the right centre back onto through balls, which will allow his stronger left foot to shoot at goal, a right footed striker doiung the same would be at a disadvantage.
If you put a right footer at STCL and told him to cut inside, then he will cut inside onto his stronger foot to shoot, having a left footer in the same position will make him cut in onto his weaker foot.
