Bruma is inconsistent. Shelvey and Sissoko can't really help your defence. You should use one truly ball winning midfielder.
Why use defensive mentality? You will never win with this mentality. I suggest to switch to counter. Deselect "Work Box Into Box", this is not good when you have to pass quickly to the strikers and they have to shoot at once, because they will not have too many opportunities. When you counter-attack, many times your most advanced player is alonem in the enemy's box and haven't good option to pass.
Also against 4231 you could use a different formation, something with a defensive midfielder, like 4-1-4-1. The defensive midfielder would be very useful to prevent their AMC to pass directly to their striker. If you insist to use 4-4-2, you could try only against 4231 or 4411 to use a partnership of stopper and cover for your center backs. Also you have to play not so narrow because you let their wingers to advance and cross from byline.
Another thing, when you play defensive or counter you should deselect "Prevent Short GK Distribution" because this makes your player to closing down very soon in the opponent's half and it stretches your team. With these mentalities you should wait your adversary in your half and when you get the ball, you should through it quickly to your strikers, before the whole defensive gets in place.
