If using the TC, I look if I should try to control the game by trying to Create space or deny it. Then I consider if I should sit back or push up. Then I decide if I should use a quicker striker to go for goal or one stronger to hold up the ball. Then I consider what kind of Midfield in my " 451/4231" that is more likely to see me achieve my goals ( DMC, DMC, MC... DMC,MC,MC... MC,MC,AMC etc). Then I decide what kind of players to use one midfield.
So you do that every game? because for me i just let my assistant pick my squad and then i pick my subs and continue to the game :/ I still win most of the time but it just feels like i'm missing out.