I agree with WJ, there's no best combination, it's all very subjective. I'm a big fan of playing a false 9 and shadow striker together. I've always wanted to try a typical big man/little man combination but never managed to get it working unfortunately.
We can offer you suggestions on a "best combination". If we know what tactical style you prefer.
Without a context, yeah there's no "best combination".
Although at a glance:
Falcao is superb in the air and at finishing.
Rooney could be more suited to building up play.
RvP offers skill on the ball.
So depending on your tactics we can then suggest roles and players for you.
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