Wigan were bringing on two attacking players when Mikel came on, should AVB have left Meireles and Lampard to defend against them? And same goes for the last one - Sturridge isn't going to offer a lot defensively and we were penned back.
Imo, yes, he should've tried to score a few more goals. You don't substitute off your most creative and arguably your best player to bring in a holding midfielder.
If anything he could've taken one of either Lampard or Meireles off.
//Edit - And you were penned back because you never, not once, tried to get forward after the goal. That's what you got wrong, Wigan grew bolder because you let them.