You're going to get pretty much the same players for this. If you play a possession "4-4-2" (don't ask me why you'd do that, but I'm going with the rules of the OP, and this is what the players seem to indicate) you'd pick Xavi as your regista if you had one. Why not Modric? More like why not Xavi. That argument in itself stops a lot of variety. You couldn't play them both especially effectively.
For the forwards, if you put Messi and Ronaldo on the wings they're both inside forwards, so you end up with 4 attackers leaving the wide areas pretty exposed, you'd be ripped apart by through balls and don't have possession. I'd say there's a serious argument of picking Schweinsteiger as box to box with someone like Alonso pinging the ball about. Younger legs than Pirlo, lets the wingers do their thing, and perhaps have a deep lying striker who drops into midfield as well. Who would I pick? Probably most of the players mentioned so far with Schweini.