Both the 4-2-2-2 and 4-2-3-1 are good for Real Madrid, from what I've seen. For 4-2-2-2, which unfortunately doesn't bring the best out of Ozil, the My Man Utd 12.0.4 works fine (you can play Ronaldo up front). I prefer 4-2-3-1 personally, consider using Raikan's Pure Perfection CCC or 4-1-3-2 Possession, you can change play Ronaldo or Di Maria as Inside Forward with attack duty to change things up as well.