Barclays Premier League
Venue: DW Stadium Date: Saturday, 26 February Kick-off: 1500 GMT
Coverage: Watch highlights on Match of the Day; listen on BBC Radio 5 live and local radio; text commentary on BBC Sport website and mobiles
Wigan defender Emmerson Boyce has a hamstring problem and will be assessed before the game, Callum McManaman is doubtful with a deep cut to his leg.
On-loan Tom Cleverley is ineligible against his parent club.
Ryan Giggs is available for Manchester United after missing the Marseille draw, and Michael Owen returns to the squad after a groin injury.
But Rio Ferdinand, Jonny Evans, Park Ji-Sung and Anderson are still not ready to play.
Doubtful: Boyce (hamstring), McManaman (cut leg)
Injured/unavailable: Cleverley (ineligible)
Injured: Anderson (knee), Evans & Valencia (both ankle), Ferdinand (calf), Hargreaves & Park (both hamstring)
Manchester United's unbeaten record may be gone, but they retain an invincible aura in Wigan's eyes. The Red Devils have won all 12 previous encounters between the sides, averaging three goals a game and conceding just four times.
It is a daunting prospect for Roberto Martinez's struggling side, who are deep in relegation trouble having won just one of their last nine league games. Martinez believes the Latics need another 13 points to secure their top-flight status, a big ask ahead of an enormously testing run of fixtures that sees them face four of the top five in their next five games.
United, too, are entering a critical phase in their season, with Saturday's visit to the DW Stadium the first in three pivotal away fixtures in succession that could define their title challenge. Sir Alex Ferguson's men follow this trip with a daunting double-header against Chelsea and Liverpool next week.
Despite suffering just one defeat all season, United's form away from home has been a cause for concern, and Ferguson has challenged Wayne Rooney and Dimitar Berbatov to make more of an impact away from Old Trafford. Both strikers are likely to be utilised here given their respective records against Wigan: Rooney has scored nine goals in 12 games against the Latics, while Berbatov has five in eight.
• Manchester United have won all 12 previous matches against Wigan, scoring 37 goals and conceding just four.
• The Latics have only scored one goal in their last seven matches against United.
• Last season's corresponding fixture ended in a 5-0 drubbing for Wigan.
• Wigan are unbeaten in their last three league matches. If they avoid defeat here it will equal their longest unbeaten run of the season.
• They have the worst defensive home record in the division, conceding 26 goals at the DW Stadium.
• Wigan's Maynor Figueroa is in line for his 100th Premier League appearance.
• Manchester United's Dimitar Berbatov (19) and Nani (9) have a total of 28 Premier League goals between them this season - one more than Wigan's total of 27.
• United have picked up 57 points from their 26 league matches - exactly the same number of points as they had at this stage last season.
• Edwin van der Sar will be making his 250th appearance in goal for Manchester United. John O'Shea is on the verge of his 250th Premier League appearance for the club.
• If involved, Gabriel Obertan will be playing on his 22nd birthday.
Rodallega: 7 goals (7 league); N'Zogbia: 5 goals (4 league)
Berbatov: 20 goals (19 league);
Hernandez: 11 goals (7 league)
Referee: Mark Clattenburg
Assistant referees: Mick McDonough & Andy Newbold
Fourth official: Anthony Taylor
LAST LEAGUE MATCH LINE-UPS
Wigan (D1-1 v Liverpool, a): Al Habsi, Gohouri, Gary Caldwell, Alcaraz, Figueroa, N'Zogbia, Watson (McArthur 72), McCarthy, Diame, Moses (Cleverley 67), Rodallega. Subs not used: Pollitt, Di Santo, Steven Caldwell, Gomez, Stam.
Man Utd (W2-1 v Manchester City, h): Van der Sar; O'Shea, Smalling, Vidic, Evra, Fletcher, Scholes (Carrick 79), Anderson (Berbatov 67), Nani, Rooney, Giggs. Subs not used: Lindegaard, Brown, Owen, Hernandez, Rafael.