I manage Pompey and on my save (2022), Everton have gone down three times, Villa went down in the second season and have never come back up. Fulham were also sent down.
Pep Guardiola took over at Liverpool and sold their best players and then left for the Spain job, and a season or two after they went down and spent two years in the Championship. And finally Chelsea who were managed by John Terry, escaped the drop by 1 point.