Yes, easily if you have players of a similar playstyle.
e.g. good winger and adapt his instruction to Messi-esque. Also have a good CM who playmakes and sits bck ect like xavi.
Im sure you could make your tactics similar to how Barcelona play but its not possible to make them exaclty like them because this is a game..not real life.
The closest downloadable tactic ive seen to how Barca play (Bear in mind the link posted is using Barca's 4-3-3, not the 4-2-3-1 they used alot this season)
try my tactic its the closetst iv got to how barca play it has
goalkeeper
full backs support
cb cover
cb stopper
defensive midfielder (through ball often)
deep lying playmaker
advanced playmaker( forward runs and run with ball oten and cross and through ball mixed)
2x inside forwards
deep lying forward or advanced forward
hope this works for you!
barca always has around 60-75% posession , this won't happen in football manager , or if it will it will be very rare , and not 75% , at least I never saw it.
I had good success with this in the matches I tried it in. It the typical 4-3-3 Barca formation and gives good possession and high pass completion percentage.
I personally prefer this formation even though it is not the conventional 4-3-3 formation. However, when you look at it IRL Iniesta tends to play slightly more advanced than Xavi or when Iniesta is injured Messi tends to occupy the AMC role. I had better results with this tactic than the above one.