well I have a game with AC Milan, use 4-1-2-1-2, have 2 champions leagues, 3 serie a's, 4 italian cup's, and thats 5 years into the game, one important note is that youth become amazing quickly, my team is:
Ochoa
De Silvestri-Sakho-Freitas (Regen?)-Dodo
Mateus (Regen?)
Canales-Cirrilo (Regen?)
Pjanic
Ortiz (Regen)- Pato
Bench:
De Gea
Boateng
Breno
Poli
Kenia
Di Gennaro
Lukaku
1 player above 25 in starting lineup and its a world class team, so you need young players!