Excellent work, certainly gave me some food for thought that I'd like to see if I can implement.
I've used a slight variation when playing a flexible 4-4-2, which works with me invariably well, which is the Deep Lying forward - Support, with a Poacher.
This combination will change give the flexibility of having someone supporting the poacher, so he wouldn't be isolated as well as a forward deep enough to be counted as a midfielder and allows me to hold the midfield against most teams.
So, if you try this combo in attack, you'll find you have the midfield grip that a 4-5-1 provides, as well as the duet up front for direct penetration of defense that the 4-4-2 provides.
It does require a very proficient striker to take up the DLF - Support role though, someone like Ibrahimovic for example, who has the dribbling ability to keep hold of the ball for long enough, or retraining a playmaker into striker position, I tried it with Coutinho and it works equally well, as he makes up for his small stature by short through balls into the box, working in the Inside forwards or the Poacher.