That would be a good test.
My tweaks are still as I said earlier in the thread, I have however been experimenting with a few things. I wouldn't take these as certain as my team is now world beating.
The CM I changed to B2B I'm still striving for perfection. A CM(s) has probably worked the best so far.
The structured / fluid thing still works really well for me, but I've found myself changing between them at times home and away. You can see sometimes (particularly in away games) that you're dominating and are going to get done!
In these games I switch to fluid (or very fluid) for 10 mins and try and grab a goal. Sometimes changing up the AMC (depending on what formation the AI is using) can help, If they are using a DM and he's getting marked out of the game, I try and get the AM free from him to create something.
None of the above are certain tweaks, just things that have worked for me.
I've won back-to-back Sextuples with the original tactic, I line up with Leo Messi (P84, G59, A46) in AMC and Mario Götze/ADM (P32, G6, A14/P68, G14, A19) & Daniel Dionisi/Mateo Kovacic (P54, G16, A16/P94, G29, A28) in MCL/MCR. Will changing one CM (A)/CM (S) to a B2B/DLP (S) and Messi to an AM (A) have a positive impact on my results? I would like more of a contribution from my CMs but as you can see, Messi seems to be doing the job at AMC and as you mentioned, the AF would score more with the absence of an SS but I find it hard to believe Falcao is going to be able to bag many more than 104 in 84 games! Oh, and 19 assists.