I've been enjoying the 4221 very much. I'm playing Wolfsburg (who are doing great in real life, by the way) and with 20 Bundesliga matches so far i've been standing between 2nd and 6th (Bayern is dominating). Haven't though got used to D-Line playing, as sometimes I'm not sure if I'm interpretating the Scout Report well and if i'm using the adequate mentality... I'm hoping with time I'll be able to understand it easily. Corner kicks are great, tank you for that!
I signed Lucas Romero and Balanta, de Bruyne has been amazing (ballon d'or candidate) and I've been playing Junior Malanda very very often and he is doing fine. Bendtner is a bit inconsistent but he was able to score about 8 goals so far.
Hope you find some time to reply and perhaps give some advice!