Niall, I normally switch to the drop formation and select 'retain possession' and 'much lower tempo'.
I tend to wait until the 75th minute to use it, and it's seen out both 2 goal and 1 goal leads.
I've even still scored a few goals with these options selected to secure all 3 points.
If you have a 3 goal lead I suppose you could use this any time after half time.
Thanks very much!
At 1-0 up v Braintree I changed to counter and puts CMs and FBs on defend and changed RPM to Dmid defend and we saw it out ok.