I'm currently working on a similar tactic and so far my results have been:
GK = Regular Goalkeeper - VDS in FM, De Gea IRL - Does not really matter
DR = Full-back (support) - Smalling IRL, Rafael in FM, Reserves for this are O'Shea and Wes Brown (Evans can be trained for it later on) if they get to play they should be limited to a defend duty as they are not very good at the offensive attributes (Crossing, Dribbling, Pace, off the ball etc.)
DCR = Ball-playing defender (defend) - Rio Ferdinand - Backup for this is Jones and Evans, Jones is a bit underrated considering his technique in fm though so it might not be such good idea to play him in this role.
DCL = Central defender (defend) - Nemanja Vidic - Backups being same as above smalling can be played here as well, he too is a bit underrated in FM as well, imo. I choose to play my center-backs with defend duty because they are so good that they will be able to make the call of going forward or staying back themselves due to their high mental attributes.
DL = full-back/Wingback (attack) - Patrice Evra - Besides being a superb player in defence Evra also shines in attack due to his ability to dribble and his mental attributes plus his immense pace, his crossing ain't so good though so i'd limit this to sometimes / rarely, he can also be played with support duty due to his PPM's in this case I’d limit his through balls to sometimes. I'm sad to do this since Evra is so good in offense IRL but in FM his distribution is horrible so it's sorta needed.
MCR = Ball-Winning Midfielder - Darren Fletcher - I've chosen this role due to Fletchers limited technique in FM, IRL i believe he plays a sort of box-to-box role or maybe just a regular midfielder role, but this role allows him to do what he's good at, pressing the opposition, intercepting passes and getting those tackles in high up the pitch. I've chosen to limit his runs with ball to rarely, since he is no dribbler but more of a hard worker, reason for support role is that we do see him join some attacks and operate higher up the pitch than his midfield partner.
MCL = Deep-lying playmaker (defend) - Carrick / Scholes - This is the recent role Ferguson have been playing these two players in, where they always stay back, rarely entering the box, always being available for a pass and distributing nice passes around the pitch as well. Considering this I’ve tinkered with putting the passing range up to full, but haven't really chosen to go with it yet.
AML = Inside-Forward (attack) - Nani in FM, IRL = Young - These are the new modern wingers seen in many teams and now also Manchester United, these two swap position and will aim to cut inside the pitch and fire off a shot or passing along to a team mate if no space is open. Besides the option going inside they are also allowed to trick the opposition defender, thereby going towards the touchline making a cross, probably a drilling one into the feet of Hernandez.
AMR = Inside-Forward / Winger (Attack) – This one depends, in the game you will mostly likely have to use Valencia meaning a winger role, but in real life Fergie is currently using Young + Nani cutting inside, but this fits well into FM because if you play either O’Shea or Brown on the right back you will probably lack width if playing inside forwards as they do lack attacking attributes.
STR = Deep-Lying Forward / Complete Forward (Support) – Rooney/Dimitar – Adjust him to maximum creative freedom and he will be working wonders up front creating chances for his teammates and scoring goals himself at will. I also use Dimitar here due to his lack in pace and great distribution ability in FM.
STL = Advanced Forward / Poacher (Attack) – Wellbeck/Hernandez/Rooney – The spearhead of the attacks played very differently depending on the player used. Rooney could eventually be used as complete forward (attack) due to his great all round ability, but he works fine as advanced forward as well, I wouldn’t recommend using him as a poacher though, since this would probably hold him back, unless given a lot creative freedom.
Wellbeck and Hernandez should probably be used as poachers in the start of the game as their passing/teamwork ability isn’t really that great, so the aspect of their game to utilize is their pace. Later on after a few seasons they both develop a lot and thereby they can join the game more, hence playing the role as Advanced Forward.
Philosophy = Fluid, this is due to the recent fluidity Ferguson have been allowing on the team, meaning his usual solid back four is being given more creative freedom, which shows by their runs up the pitch as seen in Barcelona (Pique & Puyol). It also shows up front where we’ve seen in the recent matches, that the attackers and wings have been taking defensive runs to cover up for full backs being caught high up the pitch for an example.
Starting Strategy = Control, with Counter Attacks ticked on. I will not go into depth with this as I find it obvious that united will mostly look to control their games and punish oppositions overextended with great counter attacks.
Team Instructions
Passing Style = Here I’ve been going in between shorter and default, ending up with default due to United playing a bit more direct than Barcelona, Arsenal etc. This is probably also needed due to their typical off the ball not being as high, meaning they won’t move around the pitch as well as the above mentioned teams.
Creative Freedom = More expressive, explained at the philosophy section.
Closing Down = Press More, this is like many of Fergusons recent changes in the tactic, a more global tactic used by offensive sides such as Spain, Argentina, Barcelona, Real Madrid etc. Aiming to recapture the ball fast after losing possession, preventing the opposition from building up attacks.
Marking = Zonal or Default, rather hard to determine due to it changing depending on the opposition.
Crossing = Drill crosses or default, in reality it depends on from where they set in the cross and who’s in the box, if you wanna cross to dimitar you might send in a balloon, but if you wanna distribute to Hernandez you’re gonna want a hard cross to the front post.
Roaming = More Roaming, due to the new inside forwards this is pretty obvious, ain’t worth much cutting inside if you’re supposed to stay at the flank.
I’ve ticked playmaker to none, due to united having no true playmaker, unless you consider rooney as one, though I myself do not consider the team to have a true playmaker, since Scholes has retired.
I've done quite well with the tactic winning the Champions league a few times, the league at all my attempts. At the other smaller competetions i've been using my youth players to help them develop.
My couple of few cents
Edited for more "clarity" ?
Sorry for bad english in advance.